The official name of NR4A2 gene is “nuclear receptor subfamily 4, group A, member 2". The MSH6 gene provides instructions for making a member of steroid-thyroid hormone-retinoid receptor superfamily. that may plays a role as a Trascription factor. This protein found in the brain and the adrenal gland (the hormone-producing gland located on top of each kidney). In the brain, the NR4A2 protein plays a key role in prompting certain nerve cells to specialize (differentiate) and produce a chemical messenger called dopamine. Dopamine transmits messages that help the brain control physical movement and emotional behavior.
NR4A2 prot direct interactions
Location:
NR4A2 gene is present in human chromosome 2 and its coded from region 156,889,194 to 156,897,445 base pairs with 8 exons, the cytogenetic location 2q22-q23.
Disease
Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
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