The official name of this gene is “Parkinson disease (autosomal recessive, early onset) 7.”PARK7 Gene provides informations to produce DJ-1 protein ,Studies indicate that this protein has several functions like positve regualtor of androgen receptor transcription.The DJ-1 protein helps to protect brain cells (especially neurons)from oxidative stress.Oxidative stress ocurs when unstable molecules called free radicals accumulate to levels that damage or kill cell additionaly it also function as a Chaperone molecule that helps fold newly produced proteins into the proper 3-dimensional shape and helps refold damaged proteins.Researchers also suggest that the DJ-1 protein may play a role in activities that produce and process RNA, a chemical cousin of DNA.
Location :PARK7 gene is present chromosome 1 and coded from 7944380 to 7967926 region ,the cytogenetic location is 1p36.23 ,The gene size is 23547 bp with 7 exons
Disease:
Parkinson disease is caused by mutation in PARK7 gene,reseachers had identified more than 10 PARK7 mutations that cause early-onset Parkinson disease,In some cases large portion of PARK& gene is deleted and no product is produced (functional DJ-1 Protein),other mutations creates an altered protein which doesn not function properly
Understanding Parkinson's DiseaseMode of action:
Some researchers suggest PARK7 mutations distrupt teh proteins chaperone function which leads to a toxic buildup of misfold or damaged proteins and eventually to cell death.Another possibility is that PARK7 mutations impair the protein's ability to protect cells from destructive oxidative stress. Nerve cells that make the chemical messenger dopamine are particularly vulnerable to oxidative stress. With diminished protection, free radicals may cause enough damage to kill these nerve cells. Loss of dopamine-producing nerve cells is a characteristic feature of Parkinson disease.
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