Defintion:Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Official Symbol:RNASEL
Chromosome:1
Location : 1q25
Gene Size: 13337 BP complement(155654005..155667341)
No Exons: 6
Description:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq]
Disease :
RNase L is part of the body's innate immune defense, namely the antiviral state of the cell. When a cell is in the antiviral state, it is highly resistant to viral attacks and is also ready to undergo apoptosis upon successful viral infection. Degradation of all RNA within the cell (which usually occurs with cessation of translation activity caused by protein kinase R is the cell's last stand against a virus before it attempts apoptosis.
Prostate Cancer - Radical Prostatectomy
No comments:
Write comments